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2',3,4',5,7-pentahydroxyflavone, 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one, 3,2',4',5,7-pentahydroxyflavone, morin, morin hydrate

No.	Title	Href
1	Morin Hydrate Sensitizes Hepatoma Cells and Xenograft Tumor towards Cisplatin by Downregulating PARP-1-HMGB1 Mediated Autophagy. Int J Mol Sci. 2020 Nov 4;21(21):8253. doi: 10.3390/ijms21218253.	`Click`
2	Morin Hydrate Reverses Cisplatin Resistance by Impairing PARP1/HMGB1-Dependent Autophagy in Hepatocellular Carcinoma. Cancers (Basel). 2019 Jul 15;11(7):986. doi: 10.3390/cancers11070986.	`Click`

No.

Title

Href

Morin Hydrate Sensitizes Hepatoma Cells and Xenograft Tumor towards Cisplatin by Downregulating PARP-1-HMGB1 Mediated Autophagy. Int J Mol Sci. 2020 Nov 4;21(21):8253. doi: 10.3390/ijms21218253.

Click

Morin Hydrate Reverses Cisplatin Resistance by Impairing PARP1/HMGB1-Dependent Autophagy in Hepatocellular Carcinoma. Cancers (Basel). 2019 Jul 15;11(7):986. doi: 10.3390/cancers11070986.

Click

Name	Morin Hydrate
PubChem CID	16219651
Molecular Weight	320.25g/mol
Synonyms	2',3,4',5,7-pentahydroxyflavone, 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one, 3,2',4',5,7-pentahydroxyflavone, morin, morin hydrate
Formula	C₁₅H₁₂O₈
SMILES	C1=CC(=C(C=C1O)O)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O.O
InChI	1S/C15H10O7.H2O/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15;/h1-5,16-19,21H;1H2
InChIKey	MYUBTSPIIFYCIU-UHFFFAOYSA-N
CAS Number	654055-01-3
ChEMBL ID	CHEMBL1512355
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	JiLongSang
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Rosales 　　　　-->Family: Moraceae 　　　　　-->Genus: Morus 　　　　　　-->Species: Morus serrata

Pair Name	Morin Hydrate, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Down-regulation	Expression	ATG5	hsa9474
	Down-regulation	Expression	ATG7	hsa10533
	Down-regulation	Expression	ATM	hsa472
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BECN1	hsa8678
	Up-regulation	Expression	BID	hsa637
	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	CASP9	hsa842
	Down-regulation	Expression	HMGB1	hsa3146
	Down-regulation	Expression	MAP1LC3A	hsa84557
	Up-regulation	Expression	MAP1LC3B	hsa81631
	Up-regulation	Phosphorylation	MAPK14	hsa1432
	Up-regulation	Phosphorylation	MAPK8	hsa5599
	Down-regulation	Expression	PARP1	hsa142
	Up-regulation	Expression	SQSTM1	hsa8878
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
In Vivo Model	HepG2 cells were cultured, harvested and re-suspended in sterile PBS. A total of five million cells (5 × 106) were injected into the right flank of the animals subcutaneously.
Result	Our findings indicate that CP-Mh in combination served as a prominent regulator of autophagy and significant inducer of apoptosis that maintains a homeostatic balance towards HepG2 cells and the subcutaneous tumor model.

Pair Name	Morin Hydrate, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Down-regulation	Expression	HMGB1	hsa3146
	Down-regulation	Expression	MAP1LC3A	hsa84557
	Down-regulation	Expression	MAP1LC3B	hsa81631
	Down-regulation	Expression	PARP1	hsa142
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
In Vivo Model	A total of 5×10⁶ cells were subcutaneously injected into the right flank of the mice.
Result	The combination of Morin hydrate with cisplatin may be a promising therapeutic strategy to enhance the efficacy of conventional chemotherapeutic drugs.